2021 Section Alignment
| Section 1 | Section 2 | Section 3 | Section 4 |
| McCaskey | Lebanon | Manheim Central | Annville-Cleona |
| Hempfield | Conestoga Valley | Garden Spot | Pequea Valley* |
| Manheim Township | Elizabethtown | Cocalico | Lancaster Catholic |
| Penn Manor | Ephrata | Donegal* | Columbia |
| Cedar Crest | Solanco | ELCO | Lancaster Mennonite |
| Warwick* | Lampeter-Strasburg† | Northern Lebanon | Lebanon Catholic |
| Octorara |
*2021 Section Champion
†2021 Section Champion and League Champion
2021 Softball Bracket
Current Standings courtesy Lancaster Online
LL League Softball Chairperson: Anthony Hall, AD, Solanco