Starting with the 2022 season, the Lancaster-Lebanon League will welcome our neighbors to the East from Berks county for football (only football). This will create 5 sections, aligned as follows for 2022 and 2023:
| Section 1 | Section 2 | Section 3 | Section 4 | Section 5 |
| Reading | Governor Mifflin | Elizabethtown | Cocalico | Kutztown |
| McCaskey | Lebanon | Ephrata | Lampeter-Strasburg | Northern Lebanon |
| Hempfield | Exeter | Solanco | Donegal | Hamburg |
| Manheim Township | Muhlenberg | Twin Valley | Octorara | Schuylkill Valley |
| Wilson | Warwick | Daniel Boone | Conrad Weiser | Annville-Cleona |
| Penn Manor | Conestoga Valley | Fleetwood | ELCO | Lancaster Catholic |
| Cedar Crest | Manheim Central | Garden Spot | Berks Catholic | Pequea Valley |
| Wyomissing | Columbia |
Sections 1, 2 and 3 teams will each have a BYE week during the league season, during which teams can schedule a non-section opponent.